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Volume 11, Issue 2 (Vol.11 No.2 Jul 2022)
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Naghshineh E, Dehghani Mohammadabadi R, Mehrabian F, Ghasemi Tehrani H, Tarrahi M J. Intrauterine Instillation of Human Chorionic Gonadotropin with Intrauterine Insemination Catheter Around the Golden Time of Embryo Transfer Does Not Improve In Vitro Fertilization /Intracytoplasmic Sperm Injection Outcomes in Infertile Women: A Randomized Controlled Trial. rbmb.net 2022; 11 (2) :358-366
URL: http://rbmb.net/article-1-905-en.html
URL: http://rbmb.net/article-1-905-en.html
Elham Naghshineh 
, Reihanah Dehghani Mohammadabadi , Ferdous Mehrabian , Hatav Ghasemi Tehrani * , Mohammad Javad Tarrahi
, Reihanah Dehghani Mohammadabadi , Ferdous Mehrabian , Hatav Ghasemi Tehrani * , Mohammad Javad Tarrahi
Department of Obstetrics & Gynecology, School of Medicine, Shahid Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract: (2371 Views)
Background: We set out to explore the effect of intrauterine human chorionic gonadotropin (hCG) instillation by intrauterine insemination (IUI) catheter before embryo transfer (ET) on assisted reproductive technologies (ART) outcomes of infertile women.
Methods: One hundred women with infertility who were scheduled for in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles were included in the study. They were randomly devoted to two groups: experimental (n= 50) and control (n= 50). In the experimental group, 500 IU hCG passed into the internal cervical orifice via IUI catheter within 15 minutes before the transfer of
fresh or vitrified cleavage-stage embryos. The control group underwent the same ET procedure without prior injection of hCG.
Results: None of the outcomes showed a statistically significant difference between the two groups. In the intervention and control groups, respectively, biochemical pregnancies rates were 26% and 18%, implantation rates were 13.5% and 8.6%, clinical pregnancies rates were 22% and 14%, ongoing pregnancies rates were 18% and 14%, and live birth rates were 14% and 12%.
Conclusions:Intrauterine injection of hCG via IUI catheter is not recommended in a clinical routine setting at this stage. Future efforts are warranted to further refine the applicability of this modality.
Keywords: Assisted reproductive technologies, Embryo transfer, Human chorionic gonadotropin, Intrauterine insemination catheter, Randomized clinical trial.
Type of Article: Original Article |
Subject:
Biochemistry
Received: 2022/04/3 | Accepted: 2022/04/8 | Published: 2022/08/7
Received: 2022/04/3 | Accepted: 2022/04/8 | Published: 2022/08/7
References
1. Carson SA, Kallen AN. Diagnosis and Management of Infertility: A Review. Jama. 2021;326(1):65-76. [DOI:10.1001/jama.2021.4788] [PMID] [PMCID]
2. Simon A, Laufer N. Repeated implantation failure: clinical approach. Fertil Steril. 2012;97(5):1039-43. [DOI:10.1016/j.fertnstert.2012.03.010] [PMID]
3. Hsu MI, Wang CW, Chen CH, Tzeng CR. Impact of the number of retrieved oocytes on pregnancy outcome in in vitro fertilization. Taiwan J Obstet Gynecol. 2016;55(6):821-825. [DOI:10.1016/j.tjog.2015.05.009] [PMID]
4. Schoolcraft WB. Importance of embryo transfer technique in maximizing assisted reproductive outcomes. Fertil Steril. 2016;105(4):855-60. [DOI:10.1016/j.fertnstert.2016.02.022] [PMID]
5. Makrigiannakis A, Vrekoussis T, Zoumakis E, Kalantaridou SN, Jeschke U. The Role of HCG in Implantation: A Mini-Review of Molecular and Clinical Evidence. Int J Mol Sci. 2017;18(6):1305. [DOI:10.3390/ijms18061305] [PMID] [PMCID]
6. Schumacher A, Brachwitz N, Sohr S, Engeland K, Langwisch S, Dolaptchieva M, et al. Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy. J Immunol. 2009;182(9):5488-97. [DOI:10.4049/jimmunol.0803177] [PMID]
7. Cole LA. Biological functions of hCG and hCG-related molecules. Reprod Biol Endocrinol. 2010;8:102. [DOI:10.1186/1477-7827-8-102] [PMID] [PMCID]
8. Schumacher A, Zenclussen AC. Human Chorionic Gonadotropin-Mediated Immune Responses That Facilitate Embryo Implantation and Placentation. Front Immunol. 2019;10:2896. [DOI:10.3389/fimmu.2019.02896] [PMID] [PMCID]
9. Sacchi S, Sena P, Degli Esposti C, Lui J, La Marca A. Evidence for expression and functionality of FSH and LH/hCG receptors in human endometrium. J Assist Reprod Genet. 2018;35(9):1703-1712. [DOI:10.1007/s10815-018-1248-8] [PMID] [PMCID]
10. Gao M, Jiang X, Li B, Li L, Duan M, Zhang X, et al. Intrauterine injection of human chorionic gonadotropin before embryo transfer can improve in vitro fertilization-embryo transfer outcomes: a meta-analysis of randomized controlled trials. Fertil Steril. 2019;112(1):89-97.e1. [DOI:10.1016/j.fertnstert.2019.02.027] [PMID]
11. Craciunas L, Tsampras N, Raine-Fenning N, Coomarasamy A. Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction. Cochrane Database Syst Rev. 2018;10(10):CD011537. [DOI:10.1002/14651858.CD011537.pub3] [PMID] [PMCID]
12. Abdallah KS, Makhlouf A, Badran E, El-Nashar IM, Al-Hussaini TK, Farghaly T, et al. Intrauterine injection of HCG before embryo transfer: a parallel, double-blind randomized trial. Reprod Biomed Online. 2021;43(4):663-669. [DOI:10.1016/j.rbmo.2021.06.011] [PMID]
13. Meena I, Sharma R, Baldawat A, Rehman F, Gupta A, Chauhan D. Effect of intrauterine administration of human chorionic gonadotropin (hCG) before embryo transfer on biochemical pregnancy rate, implantation rate, and clinical pregnancy rate in in vitro fertilization/intracytoplasmic sperm injection cycles: Prospective and interventional randomized comparative study. Fertility Science and Research. 2020;7(2):190-198. [DOI:10.4103/fsr.fsr_37_20]
14. Saghaei M. Random allocation software for parallel group randomized trials. BMC Med Res Methodol. 2004;4(1):26. [DOI:10.1186/1471-2288-4-26] [PMID] [PMCID]
15. McLernon DJ, Maheshwari A, Lee AJ, Bhattacharya S. Cumulative live birth rates after one or more complete cycles of IVF: a population-based study of linked cycle data from 178,898 women. Hum Reprod. 2016;31(3):572-81. [DOI:10.1093/humrep/dev336] [PMID]
16. Zeyneloglu HB, Onalan G. Remedies for recurrent implantation failure. Semin Reprod Med. 2014;32(4):297-305. [DOI:10.1055/s-0034-1375182] [PMID]
17. Licht P, Fluhr H, Neuwinger J, Wallwiener D, Wildt L. Is human chorionic gonadotropin directly involved in the regulation of human implantation?. Mol Cell Endocrinol. 2007;269(1-2):85-92. [DOI:10.1016/j.mce.2006.09.016] [PMID]
18. Simopoulou M, Sfakianoudis K, Maziotis E, Tsioulou P, Giannelou P, Grigoriadis S, et al. Investigating the Optimal Time for Intrauterine Human Chorionic Gonadotropin Infusion in Order to Improve IVF Outcome: A Systematic Review and Meta-Analysis. In Vivo. 2019;33(6):1737-1749. [DOI:10.21873/invivo.11664] [PMID] [PMCID]
19. Lu S, Peng H, Zhang H, Zhang L, Cao Q, Li R, et al. Excessive intrauterine fluid cause aberrant implantation and pregnancy outcome in mice. PLoS One. 2013;8(10):e78446. [DOI:10.1371/journal.pone.0078446] [PMID] [PMCID]
20. Marconi G, Vilela M, Belló J, Diradourián M, Quintana R, Sueldo C. Endometrial lesions caused by catheters used for embryo transfers: a preliminary report. Fertil Steril. 2003;80(2):363-7. [DOI:10.1016/S0015-0282(03)00607-1]
21. Laokirkkiat P, Thanaboonyawat I, Boonsuk S, Petyim S, Prechapanich J, Choavaratana R. Increased implantation rate after intrauterine infusion of a small volume of human chorionic gonadotropin at the time of embryo transfer: a randomized, double-blind controlled study. Arch Gynecol Obstet. 2019;299(1):267-275. [DOI:10.1007/s00404-018-4962-7] [PMID]
22. Buckett WM. A review and meta-analysis of prospective trials comparing different catheters used for embryo transfer. Fertil Steril. 2006;85(3):728-34. [DOI:10.1016/j.fertnstert.2005.08.031] [PMID]
23. Delaroche L, Oger P, Genauzeau E, Meicler P, Lamazou F, Dupont C, et al. Embryotoxicity testing of IVF disposables: how do manufacturers test?. Hum Reprod. 2020;35(2):283-292. [DOI:10.1093/humrep/dez277] [PMID]
24. Navali N, Gassemzadeh A, Farzadi L, Abdollahi S, Nouri M, Hamdi K, et al. Intrauterine administration of hCG immediately after oocyte retrieval and the outcome of ICSI: a randomized controlled trial. Hum Reprod. 2016;31(11):2520-2526. [DOI:10.1093/humrep/dew236] [PMID]
25. Hosseini R, Farzad L, Abdollahi S, Nouri M, Ghasemzadeh A, Hamdi K, et al. Effect of Intrauterine Injection of Human Chorionic Gonadotropin Before Frozen-Thawed Embryo Transfer on Implantation and Clinical Pregnancy Rate: A Randomized Controlled Trial. International Journal of Women's Health and Reproduction Sciences. 2016;4:200-203. [DOI:10.15296/ijwhr.2016.42]
26. Huang P, Wei L, Li X. A study of intrauterine infusion of human chorionic gonadotropin (hCG) before frozen-thawed embryo transfer after two or more implantation failures. Gynecol Endocrinol. 2017;33(1):67-69. [DOI:10.1080/09513590.2016.1207164] [PMID]
27. Busnelli A, Somigliana E, Cirillo F, Baggiani A, Levi-Setti PE. Efficacy of therapies and interventions for repeated embryo implantation failure: a systematic review and meta-analysis. Sci Rep. 2021;11(1):1747. [DOI:10.1038/s41598-021-81439-6] [PMID] [PMCID]
28. Kanji JN, Zelyas N, MacDonald C, Pabbaraju K, Khan MN, Prasad A, et al. False negative rate of COVID-19 PCR testing: a discordant testing analysis. Virol J. 2021;18(1):13. [DOI:10.1186/s12985-021-01489-0] [PMID] [PMCID]
29. Madjunkov M, Dviri M, Librach C. A comprehensive review of the impact of COVID-19 on human reproductive biology, assisted reproduction care and pregnancy: a Canadian perspective. Journal of Ovarian Research. 2020;13(1):140. [DOI:10.1186/s13048-020-00737-1] [PMID] [PMCID]
30. Gacci M, Coppi M, Baldi E, Sebastianelli A, Zaccaro C, Morselli S, et al. Semen impairment and occurrence of SARS-CoV-2 virus in semen after recovery from COVID-19. Hum Reprod. 2021;36(6):1520-1529. [DOI:10.1093/humrep/deab026] [PMID] [PMCID]
31. Lee WY, Mok A, Chung JPW. Potential effects of COVID-19 on reproductive systems and fertility; assisted reproductive technology guidelines and considerations: a review. Hong Kong Med J. 2021;27(2):118-126. [DOI:10.12809/hkmj209078] [PMID]
32. Dehghani Firouzabadi R, Janati S, Razi MH. The effect of intrauterine human chorionic gonadotropin injection before embryo transfer on the implantation and pregnancy rate in infertile patients: A randomized clinical trial. Int J Reprod Biomed. 2016;14(10):657-664. [DOI:10.29252/ijrm.14.10.657] [PMID] [PMCID]
33. Wirleitner B, Schuff M, Vanderzwalmen P, Stecher A, Okhowat J, Hradecký L, et al. Intrauterine administration of human chorionic gonadotropin does not improve pregnancy and life birth rates independently of blastocyst quality: a randomised prospective study. Reprod Biol Endocrinol. 2015;13:70. [DOI:10.1186/s12958-015-0069-1] [PMID] [PMCID]
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