Reports of Biochemistry
and Molecular Biology
Tue, Jul 15, 2025
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Vol.13 No.4 Jan
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El Hadji Malick Ndour * 
, Rokhaya Dione , Fatou Gueye-Tall , Sokhna Mara , Gora Fall , Coumba Kamby , El Hadji Ousmane Sene , Moustapha Djite , Nene Oumou Kesso Barry , Pape Matar Kandji , Papa Madieye Gueye , Philomene Lopez-Sall , Aynina Cisse
, Rokhaya Dione , Fatou Gueye-Tall , Sokhna Mara , Gora Fall , Coumba Kamby , El Hadji Ousmane Sene , Moustapha Djite , Nene Oumou Kesso Barry , Pape Matar Kandji , Papa Madieye Gueye , Philomene Lopez-Sall , Aynina Cisse
Department of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal.
Abstract: (50 Views)
Background: Moderately increased albuminuria is a biomarker for early onset diabetic nephropathy. The aim of this study was to evaluate the performance of use proteinuria-to-creatininuria ratio (UPCR) at different cut-off to screen for increased albuminuria using albuminuria-to-creatininuria ratio (UACR) as a gold standard.
Methods: This was a cross-sectional study. A random spot urine sample was collected from patients with type 1 diabetes to measure albuminuria and total proteinuria using respectively an immunoturbidimetric and a colorimetric assay. Albuminuria was expressed as UACR and proteinuria as UPCR. The area under the curve (AUC) method and the kappa coefficient were used to compare UPCR and UACR.
Results: In 150 diabetic patients, moderately increased albuminuria was detected in 33.3% using UACR and 35.3% using UPCR at 272 mg/g. UPCR thresholds of 130, 150, 180 and 200 mg/g yielded higher detection rates than UACR. However, all UPCR cut-offs showed low diagnostic accuracy (AUC < 70%), and agreement with UACR was mild (kappa < 0.40).
Conclusion: The level of agreement between UPCR and UACR was moderate. It is not sufficient for UPCR to replace UACR to screen for increased albuminuria in patient with type 1 diabetes.
Methods: This was a cross-sectional study. A random spot urine sample was collected from patients with type 1 diabetes to measure albuminuria and total proteinuria using respectively an immunoturbidimetric and a colorimetric assay. Albuminuria was expressed as UACR and proteinuria as UPCR. The area under the curve (AUC) method and the kappa coefficient were used to compare UPCR and UACR.
Results: In 150 diabetic patients, moderately increased albuminuria was detected in 33.3% using UACR and 35.3% using UPCR at 272 mg/g. UPCR thresholds of 130, 150, 180 and 200 mg/g yielded higher detection rates than UACR. However, all UPCR cut-offs showed low diagnostic accuracy (AUC < 70%), and agreement with UACR was mild (kappa < 0.40).
Conclusion: The level of agreement between UPCR and UACR was moderate. It is not sufficient for UPCR to replace UACR to screen for increased albuminuria in patient with type 1 diabetes.
Type of Article: Original Article |
Subject:
Biochemistry
Received: 2024/10/28 | Accepted: 2025/05/17
Received: 2024/10/28 | Accepted: 2025/05/17
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