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Davoodi A, Lotfi R, Mortazavi S H, Gorgin Karaji A, Rezaiemanesh A, Salari F. Retinoic Acid Correlates with Reduced Serum IL-10 And TGF-β in Allergic Rhinitis. rbmb.net. 2021; 9 (4) :399-407
URL: http://rbmb.net/article-1-545-en.html
Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Abstract:   (1355 Views)
Background: Retinoic acid (RA) plays a key role in naïve T cell differentiation into FOXP3+ Treg cell in the respiratory airways. The present study aims to investigate RA and Treg-related cytokine serum levels, salivary IgA levels, FOXP3 and IL-4 gene expression, and the relationships between RA serum levels and Treg-related cytokines in allergic rhinitis (AR) patients and healthy controls.

Methods: Salivary IgA and serum IgE, RA, IL-10, and TGF-β concentrations were measured by ELISA in 37 AR patients and 30 age- and sex-matched healthy controls.

Results: IL-10 and TGF-β concentrations were significantly less in AR patients than in healthy controls (p< 0.01 and P< 0.0001, respectively). Salivary IgA was significantly greater in patients than in controls (p< 0.05). RA was not significantly different between patients and controls (p> 0.05); however, a significant positive correlation was found between serum RA and both IL-10 and TGF-β in AR patients.

Conclusions: Our data suggest that RA may influence AR risk via affecting the TGF-β and IL-10 production.
Full-Text [PDF 291 kb]   (254 Downloads)    
Type of Article: Original Article | Subject: Immunology
Received: 2020/08/13 | Accepted: 2020/09/1 | Published: 2021/03/8

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