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Volume 10, Issue 2 (Vol.10 No.2 Jul 2021)
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Yousef Selim N, Farag Mannaa H, Atef Sharaki O, Zaytoun T, Elkholy N, Arafat W. Highlighting Levels of Indoxyl Sulphate among Critically Ill Patients with Acute Nephrotoxicity; Correlations Between Indoxyl Sulphate Levels and Patients’ Characteristics. rbmb.net 2021; 10 (2) :266-279
URL: http://rbmb.net/article-1-641-en.html
URL: http://rbmb.net/article-1-641-en.html
Nermien Yousef Selim 
, Hazem Farag Mannaa * , Ola Atef Sharaki , Tayseer Zaytoun , Noha Elkholy , Waleed Arafat
, Hazem Farag Mannaa * , Ola Atef Sharaki , Tayseer Zaytoun , Noha Elkholy , Waleed Arafat
Medical Biochemistry Department, Faculty of Medicine, University of Alexandria, Egypt.
Abstract: (3084 Views)
Background: Many animal studies suggested that the uremic toxin indoxyl sulphate can add to renal damage following induced nephrotoxicity and this effect has not been proved in patients with such complication.
Methods: This is a prospective, case-control, and an observational study conducted on 74 critically ill patients with acute nephrotoxicity. It was designed to measure serum levels of indoxyl sulphate on the day of enrollment and over the course of their illness using high performance liquid chromatography (HPLC-UV) and to test the correlation between these levels and patient’s demographics, clinical characteristics, physiological variables, and their outcomes.
Results: Critically ill patients with acute nephrotoxicity had significantly higher total (tIS) and free (fIS) indoxyl sulphate than healthy controls and significantly lower than patients with end-stage renal disease (ESRD). Although, no correlation was found between tIS or fIS and mortality, among survivors, tIS, fIS, creatinine and eGFR were independently associated with no renal recovery.
Conclusions: Serum indoxyl sulphate levels were elevated in critically ill patients with acute nephrotoxicity. There is an association between high levels of indoxyl sulphate and no renal-recovery outcome among survivors of acute nephrotoxicity. Early removal of indoxyl sulphate from patients’ blood may improve their outcomes.
Methods: This is a prospective, case-control, and an observational study conducted on 74 critically ill patients with acute nephrotoxicity. It was designed to measure serum levels of indoxyl sulphate on the day of enrollment and over the course of their illness using high performance liquid chromatography (HPLC-UV) and to test the correlation between these levels and patient’s demographics, clinical characteristics, physiological variables, and their outcomes.
Results: Critically ill patients with acute nephrotoxicity had significantly higher total (tIS) and free (fIS) indoxyl sulphate than healthy controls and significantly lower than patients with end-stage renal disease (ESRD). Although, no correlation was found between tIS or fIS and mortality, among survivors, tIS, fIS, creatinine and eGFR were independently associated with no renal recovery.
Conclusions: Serum indoxyl sulphate levels were elevated in critically ill patients with acute nephrotoxicity. There is an association between high levels of indoxyl sulphate and no renal-recovery outcome among survivors of acute nephrotoxicity. Early removal of indoxyl sulphate from patients’ blood may improve their outcomes.
Type of Article: Original Article |
Subject:
Biochemistry
Received: 2021/01/14 | Accepted: 2021/04/18 | Published: 2021/08/26
Received: 2021/01/14 | Accepted: 2021/04/18 | Published: 2021/08/26
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